Angiotensin I-Converting Enzyme Substrate

Angiotensin I-Converting Enzyme Substrate is a synthetic research peptide in the angiotensin family. The listed sequence/design is Bz-Phe-Ala-Pro. Angiotensin peptides are core reagents for renin-angiotensin-system research. Angiotensin II acts through AT1 and AT2 receptor subtypes, and defined truncations or substitutions are used to examine receptor recognition and peptide metabolism.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Characterization of renal angiotensin II receptors using subtype selective antagonists (PMID 1545405).
2. Mapping of angiotensin II receptor subtype heterogeneity (PMID 1577995).