Product Name | Angiopep 2 TFFYGGSRGKRNNFKTEEY |
Product Quantity | 5 mg |
Catalog Number | LT2667 |
Molecular Weight | 2301.46 |
Formula | C104H150N29O31 |
Sequence | TFFYGGSRGKRNNFKTEEY, Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-Tyr |
Purity | >95% |
CAS Number | N/A |
Product Description | The peptide TFFYGGSRGKRNNFKTEEY is part of the angiopep family derived from the Kunitz domain of human aprotinin. The peptide can cross the blood brain barrier (BBB) and was used to facilitate the delivery of pharmacological agents to the brain. Angiopep-2 interacts with low-density lipoprotein receptor-related protein 1 (LRP1), which can promote its delivery across the BBB via receptor-mediated transcytosi . Angiopep-2 has higher transcytosis capacity and higher brain volume of distribution than aprotinin. |
Scientific Background | Angiopep 2 TFFYGGSRGKRNNFKTEEY is a 19-residue synthetic peptide with the sequence Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-Tyr. The sequence contains 2 Lys and 2 Arg residues, contributing cationic character; contains 5 aromatic residues that can contribute to hydrophobic or aromatic interactions. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
