[Ala3,11,18, Nle7] Endothelin-1, human

[Ala3,11,18, Nle7] Endothelin-1, human is a synthetic research peptide in the endothelin family. The listed sequence/design is Cys-Ser-Ala-Ser-Ser-Leu-Nle-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Cys-His-Leu-Ala-Ile-Ile-Trp. Endothelin peptides are vasoactive ligands used to study ETA and ETB receptor pharmacology. Native sequences, substitutions, linearized analogs, and fragments have been used to map receptor-binding determinants.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Both ETA and ETB receptors mediate contraction to endothelin-1 (PMID 8124808).
2. [Ala1,3,11,15]endothelin-1 analogs with ETB agonistic activity (PMID 1652952).