Ac-[Tyr1,D-Arg2]-GRF (1-29) amide (human)

Ac-[Tyr1, D-Arg2]-GRF (1-29) amide (human) is a synthetic research peptide in the growth hormone-releasing hormone/factor (GHRH/GRF) family. Growth hormone-releasing hormone is a hypothalamic peptide that stimulates pituitary growth hormone synthesis and secretion through the GHRH receptor, a class B GPCR. GHRH/GRF fragments and analogs, particularly N-terminally modified forms, are used to investigate receptor activation, peptide stability, receptor binding, and structure-activity relationships.

• GHRH receptor binding and signaling assays
• growth-hormone release studies
• peptide stability and degradation experiments
• structure-activity comparisons of GHRH analogs
• LC-MS/HPLC reference applications

For fragments, substituted analogs, labeled peptides, stereochemical variants, or terminally modified forms, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. Structure and function of the growth-hormone-releasing hormone receptor
2. Growth hormone-releasing peptides--structure and kinetics