Ac-[Pro18, Asp21] Beta- Amyloid (17 - 21), amide, iAb5p Pro18 As

Ac-[Pro18, Asp21] Beta- Amyloid (17 - 21), amide, iAb5p Pro18 As is a synthetic research peptide in the amyloid-beta family. The listed sequence/design is Ac-Leu-Pro-Phe-Phe-Asp-NH2. Amyloid-beta peptides are widely used to study aggregation, oligomerization, fibril formation, sequence-dependent conformational behavior, and analytical detection relevant to Alzheimer disease research. The LPFFD beta-sheet-breaker motif has been studied as an Aβ-interacting sequence that can interfere with fibrillogenesis.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis (PMID 9662374).