Ac-PACAP-38 (human, mouse,ovine, porcine, rat)

Ac-PACAP-38 (human, mouse, ovine, porcine, rat) is a synthetic research peptide in the PACAP family. The listed sequence/design is Ac-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2. PACAP is a class B GPCR peptide ligand that activates PAC1 as well as VPAC receptors. Fragments and analogs are useful for dissecting receptor recognition and signaling.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Structural motifs of PACAP required for PAC1 receptor activation (PMID 10100920).
2. Characterization of intestinal receptors for VIP and PACAP (PMID 11193817).