Ac-IEAR-pNA

Product Name
Ac-IEAR-pNA
Product Quantity
10mg
Catalog Number
LT0848
Molecular Weight
649.7
Formula
C28H43N9O9
Sequence
 Ac-Ile-Glu-Ala-Arg-pNA, Ac-IEAR-pNA
Description
 Ac-IEAR-pNA is a peptide substrate used in laboratories to measure the activity of caspases. Ac-IEAR-pNA is also a cholinesterase inhibitor that is used to measure the activity of butyrylcholinesterase. This enzyme hydrolyzes acetylcholine into butyrylcholine and acetic acid. The Ac-IEAR-pNA peptide is the chromogenic substrate for quantifying endotoxin levels. The kinetic chromogenic endotoxin assay uses a bacterial endotoxin to activate a protease in Limulus Amebocyte Lysate (LAL) that hydrolyzes the colorless substrate Ac-Ile-Glu-Ala-Arg-pNA, resulting in the production of p-nitroaniline. The chromogenic substrate Ac-IEAR-pNA can be cleaved by human butyrylcholinesterase (HuBChE) to produce the yellow p-nitroaniline product detected at 415 nm. 
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