The Structural Basis of Peptide-Protein Binding Strategies

peptide protein binding strategy

Peptide protein binding strategies: Structure, Volume 18, Issue 2, 188-199, 10 February 2010

 

Highlights

  • After binding its partners, most peptides do not introduce any conformational changes
  • The interfaces of peptide-protein have more hydrogen bonds
  • The peptide hotspots are important for the binding
  • Peptides prefer to bind in the largest pockets on the protein surface

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