Amino acid composition of cell-penetrating peptides (CPPs)

Cell-penetrating peptides (CPPs) such as the HIV TAT peptides are able to enter cell by direct translocation and endocytosis. Click here to see details about the CPP: http://lifetein.com/Cell_Penetrating_Peptides.html

cell penetrating peptide entry mechanism

Cell Penetrating Peptides

The following table shows a selection of currently known CPPs, their origins and sequences.

Name

Origin

Sequence

Tat (48-60)

HIV-1 protein

GRKKRRQRRRPPQQ

     plsl

Igl-1 homeodomain

RVIRVWFQNKRCKDKK

STR-R8

Stearly-RRRRRRRR-amide
(Stearyl = CH3(CH2)16CO-)

STR-(RxR)4

Stearly-(RxR)4-amide
(X=6-aminohexanoic acid)

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Obesity Treatment: A New Peptide Drug

Targeted Drug Melts Fat in Obese Monkeys

Currently, only two Food and Drug Administration (FDA) approved drugs for weight loss are available in the United States: the appetite suppressant phentermine and the inhibitor of fat absorption orlistat.

An MD Anderson group designed a new peptide drug: CKGGRAKDC-GG-D(KLAKLAK)2 (termed adipotide). This is a synthetic peptide that triggers cell death. These data showed that the peptide may be useful for treating obesity in humans.

Tthe MD Anderson group used a peptide library to screen and identify regions that bind to specific vascular cells. The interaction identified will be used as effective drugs to target particular protein functions.

www.cdc.gov/CDCTV/ObesityEpidemic/

This video explains factors that have contributed to the obesity epidemic.

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