Cell-penetrating peptides (CPPs) such as the HIV TAT peptides are able to enter cell by direct translocation and endocytosis. Click here to see details about the CPP: http://lifetein.com/Cell_Penetrating_Peptides.html
Cell Penetrating Peptides
The following table shows a selection of currently known CPPs, their origins and sequences.
Currently, only two Food and Drug Administration (FDA) approved drugs for weight loss are available in the United States: the appetite suppressant phentermine and the inhibitor of fat absorption orlistat.
An MD Anderson group designed a new peptide drug: CKGGRAKDC-GG-D(KLAKLAK)2 (termed adipotide). This is a synthetic peptide that triggers cell death. These data showed that the peptide may be useful for treating obesity in humans.
Tthe MD Anderson group used a peptide library to screen and identify regions that bind to specific vascular cells. The interaction identified will be used as effective drugs to target particular protein functions.
This video explains factors that have contributed to the obesity epidemic.