Obesity Treatment: A New Peptide Drug

Targeted Drug Melts Fat in Obese Monkeys

Currently, only two Food and Drug Administration (FDA) approved drugs for weight loss are available in the United States: the appetite suppressant phentermine and the inhibitor of fat absorption orlistat.

Peptide Drug for Obesity

An MD Anderson group designed a new peptide drug: CKGGRAKDC-GG-D(KLAKLAK)2 (termed adipotide). This is a synthetic peptide that triggers cell death. These data showed that the peptide may be useful for treating obesity in humans.

Tthe MD Anderson group used a peptide library to screen and identify regions that bind to specific vascular cells. The interaction identified will be used as effective drugs to target particular protein functions.

www.cdc.gov/CDCTV/ObesityEpidemic/

This video explains factors that have contributed to the obesity epidemic.

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