Obesity Treatment: A New Peptide Drug

Targeted Drug Melts Fat in Obese Monkeys Currently, only two Food and Drug Administration (FDA) approved drugs for weight loss are available in the United States: the appetite suppressant phentermine and the inhibitor of fat absorption orlistat.

Peptide Drug for Obesity

An MD Anderson group designed a new peptide drug: CKGGRAKDC-GG-D(KLAKLAK)2 (adipotide). This is a synthetic peptide that triggers cell death. These data showed that the peptide might be helpful in treating obesity in humans. The MD Anderson group used a peptide library to screen and identify regions that bind to specific vascular cells. The interaction identified will be used as effective drugs to target particular protein functions. This video explains factors that have contributed to the obesity epidemic.

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