Product Description |
This is the most characterized fragment of the HIV transactivator protein (TAT) YGRKKRRQRRR. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. Oligomers of the TAT(47-57) peptide compact plasmid DNA to nanometric particles and stabilize DNA towards nuclease degradation. At optimized vector compositions. these peptides mediated gene delivery to cells in culture 6-8-fold more efficiently than poly-L-arginine or the mutant TAT2-M1. The HIV-tat peptide YGRKKRRQRRR is a powerful tool in biotechnology and medicine, primarily due to its cell-penetrating capabilities. Its applications range from genetic engineering in microalgae to enhancing drug delivery and protecting against UV-induced skin damage. The ongoing research into its uptake mechanisms and potential uses in various fields highlights its versatility and importance in scientific advancements. |
