Ret Rabbit mAb

Product Name	Ret Rabbit mAb
Catalog Number	LTA24707
Quantity	100ul
Price	$750 In stock
Description	This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
Alias	PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1
Keywords	5979,sc-1290,sc-13104,sc-167,RET,CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51,ret proto-oncogene,proto-oncogene tyrosine-protein kinase receptor Ret,CUX1/RET fusion,RET receptor tyrosine kinase,RET transforming sequence,cadherin family member 12,cadherin-related family member 16,hydroxyaryl-protein kinase,proto-oncogene c-Ret,rearranged during transfection,receptor tyrosine kinase,ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1,Hirschsprung disease),P07949,Ret Proto-Oncogene,Cadherin-Related Family Member 16,Rearranged During Transfection,RET Receptor Tyrosine Kinase,Cadherin Family Member 12,Proto-Oncogene C-Ret,Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1,Hirschsprung Disease),Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1,Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret,Hirschsprung Disease 1,EC 2.7.10.1
Gene Template Species	Human
Gene/Protein ID	5979
SWISS ID	P07949
Antigen Sequence	DISKDLEKMM VKRRDYLDLA ASTPSDSLIY DDGLSEEETP LVDCNNAPLP RALPSTWIEN KLYGMSDPNW PGESPVPLTR ADGTNTGFPR YPNDSVYANW M
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Ret (NP_066124.1).
Animal Source	Rabbit
Antibody Type	Affinity Purified Monoclonal IgG
Applications	WB, ELISA
Cross-Reactivity	Mouse, Rat
Molecular Weight	124kDa
Recommended Dilution	WB,1:1000 - 1:4000\|ELISA,Recommended starting concentration is 1 _g/mL. Please optimize the concentration based on your specific assay requirements.
Stability and Storage	Reconstituted antibodies stable at -80C for 12 months, 4C for 1 week. Avoid repeated freeze-thaw cycles.
Shipping	Shipped at ambient temperature.
Reconstitution	Centrifuge tubes before opening. Dissolve the lyophilized antibodies in distilled water. 5-10% glycerol is recommended.
Image	Western blot analysis of various lysates using Ret Rabbit mAb (LTA24707) at 1:1000 dilution incubated overnight at 4_.\|Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (LT014) at 1:10000 dilution.\|Lysates/proteins: 25 _g per lane.\|Blocking buffer: 3% nonfat dry milk in TBST.\|Detection: ECL Basic Kit (LT00020).\|Negative control (NC): K-562\|Exposure time: 30s.

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Ret Rabbit mAb

$750.00