| LT13511 |
| 1 MG |
| Recombinant TGF β1 (Transforming Growth Factor-β1 ) |
| Cartilage-inducing factor, Differentiation inhibiting factor |
| Human |
| Human Transforming Growth Factor-b1 (TGF-b1) is a member of a superfamily of homologous, disulfide-linked, homo-dimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. TGF-β1 is synthesized in cells as a 390-amino acid precursor. The protein undergoes a number of intracellular processing steps including proteolytic digestion of the precursor yielding two products that assemble into dimers. The 65–75 kDa N-terminal cleavage product corresponds to the latency-associated peptide (LAP), and the 25-kDa C-terminal portion of the precursor constitutes
the mature TGF- β1. |
| ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS |
| 25 kDA, glycosylated |
| Chinese Hamster Ovary cells |
| >95%, Determined by SDS‐PAGE under reducing conditions and visualized by silver stain. |
| Endotoxin Level < 1.0 EU per 1 μg of the protein by the LAL method |
| Sterile filtered 0.22 um filter in 20 mM TRIS*HCl buffer pH 7.2. Activated in vitro at pH below 3.5 and over 12.5. |
| The ED50 is typically 20-60 ng/mL before activation and 0.1‑1 ng/mL after activation. |
|  |
| ‐20°C to ‐80°C |
| For research purposes only! Not for human or animal therapeutic or diagnostic use. |
