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| This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. |
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| 3932,sc-32014,sc-13,sc-28882,LCK,LSK,p56 LCK,p56lck,pp58lck,Protein YT16,Proto oncogene Lck,Tyrosine protein kinase Lck,YT16,IMD22,LCK proto-oncogene,Src family tyrosine kinase,tyrosine-protein kinase Lck,T-lymphocyte specific protein tyrosine kinase p56lck,leukocyte C-terminal Src kinase,lymphocyte cell-specific protein-tyrosine kinase,p56(LSTRA) protein-tyrosine kinase,proto-oncogene tyrosine-protein kinase LCK,t cell-specific protein-tyrosine kinase,P06239,LCK Proto-Oncogene,Src Family Tyrosine Kinase,Lymphocyte Cell-Specific Protein-Tyrosine Kinase,T Cell-Specific Protein-Tyrosine Kinase,Leukocyte C-Terminal Src Kinase,T-Lymphocyte Specific Protein Tyrosine Kinase P56lck,Lymphocyte-Specific Protein Tyrosine Kinase,Proto-Oncogene Tyrosine-Protein Kinase LCK,P56(LSTRA) Protein-Tyrosine Kinase,Tyrosine-Protein Kinase Lck,Proto-Oncogene Lck,EC 2.7.10.2,Pp58lck,P56-LCK,P56lck |
