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| CD299/DC-SIGNR Rabbit mAb |
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| LTA24823 |
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| 100ul |
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$750
In stock
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| This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. |
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| CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR |
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| 10332,CLEC4M,CD209L,CD299,DC-SIGN2,DC-SIGNR,DCSIGNR,HP10347,L-SIGN,LSIGN,C-type lectin domain family 4 member M,CD209 antigen-like protein 1,CD299 antigen,DC-SIGN-related protein,dendritic cell-specific ICAM-3-grabbing non-integrin 2,liver/lymph node-specific ICAM-3 grabbing non-integrin,mannose binding C-type lectin DC-SIGNR,Q9H2X3,C-Type Lectin Domain Family 4 Member M,CD299 Antigen,Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 2,CD209 Antigen-Like Protein 1,DC-SIGN-Related Protein,Liver/Lymph Node-Specific ICAM-3 Grabbing Non-Integrin,Liver/Lymph Node-Specific ICAM-3-Grabbing Non-Integrin,C-Type Lectin Domain Family 4,Member M,Mannose Binding C-Type Lectin DC-SIGNR,CD209L1 |
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| Human |
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| 10332 |
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| Q9H2X3 |
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| QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE |
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| Recombinant fusion protein containing a sequence corresponding to amino acids 71-399 of human DC-SIGNR/CD299 (NP_055072.3). |
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| Rabbit |
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| Affinity Purified Monoclonal IgG |
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| WB, IF/ICC, ELISA |
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| Human, Rat, WideRange |
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| 45kDa |
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| WB,1:1000 - 1:3000|IF/ICC,1:100 - 1:400|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
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Reconstituted antibodies stable at -80C for 12 months, 4C for 1 week. Avoid repeated freeze-thaw cycles.
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Shipped at ambient temperature.
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Centrifuge tubes before opening. Dissolve the lyophilized antibodies in distilled water. 5-10% glycerol is recommended.
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| .jpg )
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with CD299/DC-SIGNR using CD299/DC-SIGNR Rabbit mAb (LTA24823) at 1:3000 dilution incubated overnight at 4_.|Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (LT014) at 1:10000 dilution.|Lysates/proteins: 20 _g per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (LT00020)|.Exposure time: 180s. |
