Anti-human cTnI Monoclonal Antibody (clone 5A16)

$250.00

Catalog Number:
LT_R016
Quantity:
50ug
Immunogen:
Full length native human cTnI protein
IgG type:
Rabbit IgG
Clonality:
Monoclonal
Applications:
ELISA, ITA
Pairing antibody:
clone 5D11
Specificity:
Human cTnI
Formulation:
0.22 μM filtered solution of PBS, pH 7.4
Purity:
> 95% determined by SDS-PAGE
Storage:

This antibody is shipped at 4 °C. This product is stable for 12 months from date of receipt when stored at -20 °C to -70 °C. Avoid freeze/thaw cycles.

Preparation:

Monoclonal antibody is produced by immunizing rabbit with full length human cTnI and purified using protein A resin.

Hazard/Biohazard:

This antibody contains 0.09% sodium azide as preservative. Please handle and dispose the product properly. No known biohazard is associated with this product.

Background:

Cardiac troponin I, cTnI, is exclusively expressed in cardiac
muscle tissue in a single isoform with molecular weight ~24
KD. cTnI forms complex with cardiac Troponin T (cTnT) and
Troponin C (TnC) to regulate the formation of actomyosin
filament and subsequent cardiac muscle contraction. During
cardiac muscle tissue injury, cTnI is released into the blood
of patient and indicative of cardiac cell death. cTnI has been
widely used as a sensitive and specific diagnostic marker of
acute myocardial infarction (AMI), post-surgery myocardium
trauma, chemotherapy cardiotoxicity, and some other
diseases linked to cardiac muscle injury. In recent years,
high-sensitivity cTnI assay has been used to accurately
diagnose AMI after the onset of acute chest pain.

Images:


Fig. 1 ELISA

ELISA conditions
1) capture antibody: rabbit anticTnI monoclonal antibody (clone 5D11) at 1 μg/ml
2) detection antibody: rabbit anti-cTnI monoclonal antibody (clone 5A16, LT_R016) at 0.5 μg/ml


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  • 4 Units in Stock

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