Angiotensin-converting-enzyme-2 (ACE2)


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coronavirus peptide ACE2

Angiotensin-converting enzyme 2 (ACE2): A recent study has confirmed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses severe acute respiratory syndrome coronavirus (SARS-CoV) receptor angiotensin-converting enzyme 2 (ACE2) for host cell entry. Understanding how the new coronavirus exploits ACE2 is powerful information. Usually, ACE2 is found on lung, kidney, heart, and gut cells. Recently, researchers discovered ACE2 receptors on the cells in the nose. Decoy ACE2 receptors could be promising COVID-19 infection-preventing drugs.

Reference: Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides

LifeTein can help in your research with custom peptide synthesis of the following specific proteins: SARS-CoV-2 Receptor Binding Domains, SARS-CoV-2 Nucleocapsid Fragments, T-cell and B-cell Epitopes of SARS-CoV-2, Fusion Inhibitors Targeting HR1 Domain of the SARS-CoV-2 Spike Proteins, Inhibitors of SARS-CoV-2 Mpro/3CLpro/C30 Endopeptidase, ACE2 Inhibitors and Substrates, and AT2 Receptor Agonists and Antagonists. Please email to sales@lifetein.com for a price quotation.

Angiotensin I Converting Enzyme II Substrate

Fluorescence-Quenching Substrate for ACE21: Abz-Gly-Phe-Ser-Pro-Tyr(NO2)-OH; Mca - APK(Dnp); Abz-Ser-Pro-Tyr(NO2)-OH

Angiotensin II (Human): Asp-Arg-Val-Tyr-Ile-His-Pro-Phe;

ACE2 Inhibitor: Ac - GDYSHCSPLRYYPWWKCTYPDPEGGG - NH2

Angiotensin (Human, 1-7): Asp-Arg-Val-Tyr-Ile-His-Pro, FORMULA: C41H62N12O11; MOLECULAR WEIGHT: 899.02; CAS REGISTRY NUMBER: [51833-78-4]; Angiotensin (1-7) acts as a vasodilator in the cardiovascular system and plays a significant role in the renin-angiotensin system (RAS). More recently, Angiotensin II (Ang II) is thought to play a role in preventing SARS-CoV-2 infection by binding to ACE2 receptors in the host cell. Since SARS-CoV-2 virus binds to ACE2 receptors, with 10–20 times the affinity of SARS-CoV-1 (ie: SARS-CoV), peptide-binding may, therefore, compete with the virus. Ang II is also known to bind to the AT1 receptor which causes internalization and downregulation of ACE2.

Angiotensin I (Human): Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu; DRVYIHPFHL

Furin Substrates and Inhibitors: Boc-Gln-Arg-Arg-MCA; Boc-Leu-Lys-Arg-MCA; Boc-Arg-Val-Arg-Arg-MCA; Pyr-Arg-Thr-Lys-Arg-MCA

RGD Peptides: Cyclo(Arg-Ala-Asp-D-Phe-Lys); Cyclo(Arg-Ala-Asp-D-Phe-Val); Cyclo(Arg-Ala-Asp-D-Tyr-Cys)<; Cyclo(Arg-Gly-Asp-D-Phe-Lys)/p>

Dabcyl-Lys-SARS-CoV2 Replicase pp1ab (3235-3246)-Glu-EDANS: Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS (trifluoroacetate salt); SEQUENCE: Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS; ONE-LETTER SEQUENCE: Dabcyl-KTSAVLQSGFRKME-EDANS; MOLECULAR FORMULA: C95H141N25O24S2; MOLECULAR WEIGHT: 2081.44; CAS REGISTRY NUMBER: [730985-86-1]

SARS Main Protease Fluorogenic Substrate: SEQUENCE: MCA-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys(Dnp)-Lys-NH2; ONE-LETTER SEQUENCE: MCA-AVLQSGFR-K(Dnp)-K-NH2; MOLECULAR FORMULA: C69H99N19O20; MOLECULAR WEIGHT: 1514.66

SARS-CoV Spike Protein Epitope KRSFIEDLLFNKV: SEQUENCE: H-Lys-Arg-Ser-Phe-Ile-Glu-Asp-Leu-Leu-Phe-Asn-Lys-Val-OH (trifluoroacetate salt); ONE-LETTER SEQUENCE: KRSFIEDLLFNKV; MOLECULAR FORMULA: C75H122N20O19; MOLECULAR WEIGHT: 1607.92; Description: KRSFIEDLLFNKV is a highly conserved epitope of SARS-CoV and SARS-CoV-2 Spike Protein. The KRSFIEDLLFNKV protein subsequence is exposed on the viral surface and is required for proteolytic activation cleavage and host cell entry. Because the epitope remains exposed intermolecular protein interactions (in the “open” spike protein state) and is required for host entry, it is less likely to undergo productive mutations making it an attractive target for peptide-based vaccine development.

SARS-CoV-2 Mpro Protease Substrate Ac-Abu-Tle-Leu-Gln-ACC: SEQUENCE: Ac-Abu-Tle-Leu-Gln-ACC; ONE-LETTER SEQUENCE: Ac-Abu-Tle-LQ-ACC; MOLECULAR FORMULA: C34H49N70O9; MOLECULAR WEIGHT: 699.81

SARS-CoV-2 Mpro Protease Substrate Ac-Thz-Tle-Leu-Gln-ACC: SEQUENCE: Ac-Thz-Tle-Leu-Gln-ACC; ONE-LETTER SEQUENCE: Ac-Thz-ILQ-ACC; MOLECULAR FORMULA: C34H47N7O9S; MOLECULAR WEIGHT: 729.85

SARS-CoV-2 Mpro Protease Substrate Ac-Val-Lys-Leu-Gln-ACC: SEQUENCE: Ac-Val-Lys-Leu-Gln-ACC; ONE-LETTER SEQUENCE: Ac-VKLQ-ACC; MOLECULAR FORMULA: C35H52N8O9; MOLECULAR WEIGHT: 728.85

Decanoyl-Arg-Val-Lys-Arg-chloromethylketone: Description: Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication). SEQUENCE: Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt); ONE-LETTER SEQUENCE: Decy-RVKR-CMK; MOLECULAR FORMULA: C34H66Cl1N11O5; MOLECULAR WEIGHT: 744.4

coronavirus peptide ACE2

coronavirus peptide pool

The key receptor-binding domain (residues 319-541) is highlighted in yellow. Variable amino acid residues between SARS-CoV-2 and SARS-CoV are highlighted in cyan. Tyr 489, Asn 487, Gln 493, Tyr 505 are important for ACE2 binding.


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