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Strategies for the Synthesis of Labeled Peptides

Feb 14, 2014
LifeTein Life Chat agent wrote
Labeled peptides are frequently used by researchers for binding studies, to determine substrate specificity, and for receptor cross-linking studies. Many researchers would like to synthesize a biotin, FITC, nanoparticle, or drug-labeled peptide. It is suggested that a new strategy, using Rink amide 4-methylbenzhydrylamine resin coupled with Fmoc-Lys(Dde)-OH, be used. The major advantage of this approach is that other labels such as fluorescein, dansyl groups, methyl coumarin, and potentially fluorophores and quenchers used for fluorescence resonance energy transfer (FRET) can be directly incorporated into peptides.
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