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Does LifeTein offer antigen design assistance?

Jun 10, 2013
LifeTein Life Chat agent wrote

We will analyze your protein sequence and recommend the most immunogenic sequences based on such factors as the hydrophobicity / hydrophilicity and folding characteristics of the protein. We provide this service at no additional charge.

Generating antibodies against a full-length protein will provide a pool of antibodies against multiple epitopes from the protein. Immunizing with a peptide sequence, by contrast, allows the serum to be affinity purified against the peptide sequence, thereby permitting isolation of antibodies that are highly specific to the target protein. The potential downside to this approach is that there is a risk that the chosen sequence won’t correspond to an exposed region of the native protein.
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