{"id":975,"date":"2021-11-16T11:38:11","date_gmt":"2021-11-16T16:38:11","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=975"},"modified":"2024-11-16T21:25:29","modified_gmt":"2024-11-17T02:25:29","slug":"lifeteins-peptides-and-antibodies-help-scientists-fight-dementia-causing-pathogens-in-zebrafish-model","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/lifeteins-peptides-and-antibodies-help-scientists-fight-dementia-causing-pathogens-in-zebrafish-model\/","title":{"rendered":"LifeTein\u2019s Peptides and Antibodies Help Scientists Fight  Dementia-causing Pathogens in Zebrafish Model"},"content":{"rendered":"<div class=\"wp-block-image is-resized\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"349\" height=\"145\" src=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2021\/11\/image-1.png\" alt=\"Peptides and Antibodies\" class=\"wp-image-979\" srcset=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2021\/11\/image-1.png 349w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2021\/11\/image-1-300x125.png 300w\" sizes=\"(max-width: 349px) 100vw, 349px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Neurodegeneration in postmortem patients of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) has been correlated to distribution of dipeptide repeat proteins in the form of poly-GR. Scientists at the Erasmus University Medical Center Rotterdam have assessed the toxicity of poly-GR and found a possible suppression with the help of zebrafish, Trolox, and LifeTein\u2019s own GR peptides and antibodies.<br \/><br \/>Trolox Suppresses Poly-GR Toxicity Identified by Antibodies<strong><br \/><\/strong><br \/>Using zebrafish as a model for C9FTD\/ALS cases, scientists injected the embryos with RNA encoding ATG mediated codon-optimized 100xGR. <a href=\"https:\/\/www.lifetein.com\/peptide_synthesis_services.html\" target=\"_blank\" rel=\"noopener\" title=\"\">These peptides provided by LifeTein<\/a> were able to simulate the apoptosis in the brain and caused aberrant motor neuron morphology in the zebrafish embryos. Using LifeTein\u2019s monoclonal antibody against poly-GR, the group was able to detect the poly-GR specifically in the brain. <br \/><br \/>The researchers\u2019 study suggested inhibition of oxidative stress held the potential to suppress the poly-GR toxicity in these models. To apply this knowledge, the embryos were treated with Trolox, a known inhibitor of oxidative stress. Not only did this rescue the poly-GR toxicity, but it did so in vivo. This holds a promising future in treatment of C9FTD\/ALS patients, indicating the possible role of oxidative stress implies the possible treatment by inhibiting the said stress.<br \/><br \/>References: Riemslagh FW, Verhagen RFM, van der Toorn EC, Smits DJ, Quint WH, van der Linde HC, van Ham TJ, Willemsen R. Reduction of oxidative stress suppresses poly-GR mediated toxicity in zebrafish embryos. Dis Model Mech. 2021 Oct 25:dmm.049092. doi: 10.1242\/dmm.049092. Epub ahead of print. PMID: 34693978.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurodegeneration in postmortem patients of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) has been correlated to distribution of dipeptide repeat proteins in the form of poly-GR. Scientists at the Erasmus University Medical Center Rotterdam have assessed the toxicity of &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/lifeteins-peptides-and-antibodies-help-scientists-fight-dementia-causing-pathogens-in-zebrafish-model\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":6,"featured_media":979,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=975"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/975\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/979"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}