{"id":695,"date":"2020-09-28T12:38:25","date_gmt":"2020-09-28T16:38:25","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=695"},"modified":"2024-11-16T21:31:48","modified_gmt":"2024-11-17T02:31:48","slug":"the-pivotal-role-of-tmprss2-in-covid19","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/the-pivotal-role-of-tmprss2-in-covid19\/","title":{"rendered":"The pivotal role of TMPRSS2 in COVID19"},"content":{"rendered":"\n

Transmembrane serine protease 2 (TMPRSS2) is a serine protease that in humans is encoded by the TMPRSS2 gene. It is a cell surface protein primarily expressed by endothelial cells across the respiratory and digestive tracts. The protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain.<\/p>\n\n\n\n

Recent evidence suggested that SARS-CoV-2 uses the ACE2 receptor for cell entry, in synergy with the host\u2019s TMPRSS2. The viral S glycoprotein is cleaved by TMPRSS2, thus facilitating viral activation. As TMPRSS2 is a serine protease, it primes the spike-domain (S) of SARS-CoV-2 by cleaving as the S1\/S2 sites. TMPRSS2 activity is crucial for cell entry and viral pathogenesis. In a recent in vitro study by Hoffmann et al., the TMPRSS2 inhibitor camostat mesylate blocked the SARS-CoV-2 entry into primary lung cells, suggesting that TMPRSS2 could represent a potential target in SARS-CoV-2 treatment. This drug is approved for clinical use already in Japan for unrelated illnesses and could serve to be an important therapy for COVID-19.<\/p>\n\n\n\n

\"TMPRSS2
SARS-CoV-2 uses the ACE2 receptor for cell entry, in synergy with the host\u2019s TMPRSS2<\/figcaption><\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Transmembrane serine protease 2 (TMPRSS2) is a serine protease that in humans is encoded by the TMPRSS2 gene. It is a cell surface protein primarily expressed by endothelial cells across the respiratory and digestive tracts. The protein contains a type … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":696,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\n","aioseo_head_json":{"title":"LifeTein provides affordable recombinant ACE2 and TMPRSS2 | LifeTein Peptide Blog","description":"SARS-CoV-2 uses the ACE2 receptor for cell entry in synergy with the host\u2019s TMPRSS2. LifeTein provides TMPRSS2 and ACE2 recombinant protein for COVID19 research","canonical_url":"https:\/\/www.lifetein.com\/blog\/the-pivotal-role-of-tmprss2-in-covid19\/","robots":"max-image-preview:large","keywords":"tmprss2,covid19,sars-cov-2,ace2 receptor","webmasterTools":{"google-site-verification":"xKDW6DUiGuZ6nwglNeWlVWTgzTtMPzas13ROL63ytTc","msvalidate.01":"5B15601215D876311F84CFEFB0F72F18","miscellaneous":""},"schema":null,"og:locale":"en_US","og:site_name":"LifeTein Peptide Synthesis Blog","og:type":"article","og:title":"LifeTein provides affordable recombinant ACE2 and TMPRSS2 | LifeTein Peptide Blog","og:description":"SARS-CoV-2 uses the ACE2 receptor for cell entry in synergy with the host\u2019s TMPRSS2. LifeTein provides TMPRSS2 and ACE2 recombinant protein for COVID19 research","og:url":"https:\/\/www.lifetein.com\/blog\/the-pivotal-role-of-tmprss2-in-covid19\/","fb:admins":"233983946638783","og:image":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg","og:image:secure_url":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg","article:tag":["tmprss2","covid19","sars-cov-2","ace2 receptor","peptide"],"article:published_time":"2020-09-28T16:38:25+00:00","article:modified_time":"2024-11-17T02:31:48+00:00","article:publisher":"https:\/\/www.facebook.com\/LifeTein-LLC-233983946638783\/","twitter:card":"summary_large_image","twitter:site":"@lifetein","twitter:title":"LifeTein provides affordable recombinant ACE2 and TMPRSS2 | LifeTein Peptide Blog","twitter:description":"SARS-CoV-2 uses the ACE2 receptor for cell entry in synergy with the host\u2019s TMPRSS2. LifeTein provides TMPRSS2 and ACE2 recombinant protein for COVID19 research","twitter:creator":"@lifetein","twitter:image":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg"},"aioseo_meta_data":{"post_id":"695","title":"LifeTein provides affordable recombinant ACE2 and TMPRSS2 | #site_title","description":"SARS-CoV-2 uses the ACE2 receptor for cell entry in synergy with the host\u2019s TMPRSS2. LifeTein provides TMPRSS2 and ACE2 recombinant protein for COVID19 research","keywords":[{"label":"TMPRSS2","value":"TMPRSS2"},{"label":"COVID19","value":"COVID19"},{"label":"SARS-CoV-2","value":"SARS-CoV-2"},{"label":"ACE2 receptor","value":"ACE2 receptor"}],"keyphrases":{"focus":{"keyphrase":"TMPRSS2","score":85,"analysis":{"keyphraseInTitle":{"score":9,"maxScore":9,"error":0},"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInURL":{"score":5,"maxScore":5,"error":0},"keyphraseInIntroduction":{"score":9,"maxScore":9,"error":0},"keyphraseInSubHeadings":[],"keyphraseInImageAlt":{"score":9,"maxScore":9,"error":0},"keywordDensity":{"type":"high","score":0,"maxScore":9,"error":1}}},"additional":[{"keyphrase":"TMPRSS2","score":80,"analysis":{"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInIntroduction":{"score":9,"maxScore":9,"error":0},"keyphraseInImageAlt":{"score":9,"maxScore":9,"error":0},"keywordDensity":{"type":"high","score":0,"maxScore":9,"error":1}}},{"keyphrase":"COVID19","score":67,"analysis":{"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":{"score":9,"maxScore":9,"error":0},"keywordDensity":{"score":0,"type":"low","maxScore":9,"error":1}}},{"keyphrase":"ACE2","score":73,"analysis":{"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":{"score":3,"maxScore":9,"error":1},"keywordDensity":{"type":"best","score":9,"maxScore":9,"error":0}}},{"keyphrase":"LifeTein","score":53,"analysis":{"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":{"score":3,"maxScore":9,"error":1},"keywordDensity":{"score":0,"type":"low","maxScore":9,"error":1}}}]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"article","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":true,"twitter_card":"summary_large_image","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"Article","isEnabled":true},"graphs":[]},"schema_type":"none","schema_type_options":"{\"article\":{\"articleType\":\"BlogPosting\"},\"course\":{\"name\":\"\",\"description\":\"\",\"provider\":\"\"},\"faq\":{\"pages\":[]},\"product\":{\"reviews\":[]},\"recipe\":{\"ingredients\":[],\"instructions\":[],\"keywords\":[]},\"software\":{\"reviews\":[],\"operatingSystems\":[]},\"webPage\":{\"webPageType\":\"WebPage\"},\"book\":[],\"event\":[],\"jobPosting\":[],\"music\":[],\"person\":[],\"restaurant\":[],\"service\":[],\"video\":[]}","pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"0","robots_max_imagepreview":"none","priority":null,"frequency":"default","location":null,"local_seo":null,"seo_analyzer_scan_date":null,"breadcrumb_settings":null,"limit_modified_date":false,"open_ai":"{\"title\":{\"suggestions\":[],\"usage\":0},\"description\":{\"suggestions\":[],\"usage\":0}}","ai":null,"created":"2020-12-04 22:27:30","updated":"2025-06-18 02:55:22"},"aioseo_breadcrumb":"

\n\t\t\tHome<\/a>\n\t\t<\/span>»<\/span>\n\t\t\tPeptide<\/a>\n\t\t<\/span>»<\/span>\n\t\t\tThe pivotal role of TMPRSS2 in COVID19\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/www.lifetein.com\/blog"},{"label":"Peptide","link":"https:\/\/www.lifetein.com\/blog\/category\/peptide_synthesis\/"},{"label":"The pivotal role of TMPRSS2 in COVID19","link":"https:\/\/www.lifetein.com\/blog\/the-pivotal-role-of-tmprss2-in-covid19\/"}],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=695"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/695\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/696"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}