{"id":690,"date":"2020-08-27T15:14:03","date_gmt":"2020-08-27T19:14:03","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=681"},"modified":"2024-11-16T21:32:10","modified_gmt":"2024-11-17T02:32:10","slug":"receptor-binding-domains-of-sars-cov-2-lt5578-cited-by-nature","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/receptor-binding-domains-of-sars-cov-2-lt5578-cited-by-nature\/","title":{"rendered":"Receptor-binding Domains of SARS-CoV-2, LT5578, Cited by Nature"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). It is a critical determinant of virus-receptor interaction and thus of viral host range and tropism. The RBD also includes important viral-neutralizing epitopes (21\u201323), and it may be sufficient to raise a protective antibody response in inoculated animals.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Two potently neutralizing monoclonal antibodies, COV2-2196 and COV2-2130, which recognize non-overlapping sites, bound simultaneously to the S protein and neutralized wild-type SARS-CoV-2 virus in a synergistic manner.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lately, a recombinant SARS-CoV-2 Spike S (S1+S2) Protein was produced by LifeTein. The amino acid sequences of recombinant protein was derived from (Q14 &#8211; Q1208) of accession# YP009724390.1. The SARS-CoV-2 spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV-2 (2019-nCoV) as in recent COVID-19 outbreak.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/08\/SARS-CoV-2-structure.jpg\" alt=\"SARS-CoV-2 receptor binding domain structure\" class=\"wp-image-682\"\/><figcaption>Schematic of the SARS-CoV-2 structure; the illustration of the virus is available at doi: https:\/\/doi.org\/10.1371\/journal.ppat.1008762.g003.<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/receptor-binding-domains-of-sars-cov-2-lt5578-cited-by-nature\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":687,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-690","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). It is a critical determinant of virus-receptor interaction and thus of viral host A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). 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This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). It is a critical determinant of virus-receptor interaction and thus of viral host A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). 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This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). It is a critical determinant of virus-receptor interaction and thus of viral host A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). 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It is a critical determinant of virus-receptor interaction and thus of viral host A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). 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This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). It is a critical determinant of virus-receptor interaction and thus of viral host A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443\u2013449(2020)). This peptide was synthesized in 6 days. This is part of the receptor-binding domain (RBD). 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22:27:30","updated":"2025-06-18 02:55:22"},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.lifetein.com\/blog\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.lifetein.com\/blog\/category\/peptide_synthesis\/\" title=\"Peptide\">Peptide<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tReceptor-binding Domains of SARS-CoV-2, LT5578, Cited by Nature\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/www.lifetein.com\/blog"},{"label":"Peptide","link":"https:\/\/www.lifetein.com\/blog\/category\/peptide_synthesis\/"},{"label":"Receptor-binding Domains of SARS-CoV-2, LT5578, Cited by 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