{"id":665,"date":"2020-02-21T13:29:50","date_gmt":"2020-02-21T18:29:50","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=665"},"modified":"2024-11-16T21:35:01","modified_gmt":"2024-11-17T02:35:01","slug":"2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor\/","title":{"rendered":"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor"},"content":{"rendered":"\n
\"2019-nCoV
2019-nCoV Coronavirus Receptor -Binding Motif<\/figcaption><\/figure>\n\n\n\n

The extensive structural analyses have revealed that interactions between SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. <\/p>\n\n\n\n

Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2 as its receptor with much higher affinity (10-20 times higher!) than SARS.<\/p>\n\n\n\n

Several critical residues in 2019-nCoV RBM may provide favorable interactions with human ACE2 such as Gln493 and Asn501. <\/p>\n\n\n\n

A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the \u03b2 sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.<\/p>\n","protected":false},"excerpt":{"rendered":"

The extensive structural analyses have revealed that interactions between SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. Studies showed that the sequence of 2019-nCoV … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":666,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-665","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\n","aioseo_head_json":{"title":"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor | LifeTein Peptide Blog2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor","description":"A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the \u03b2 sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.The extensive structural analyses have revealed that interactions between SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2","canonical_url":"https:\/\/www.lifetein.com\/blog\/2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor\/","robots":"max-image-preview:large","keywords":"2019-ncov,coronavirus,receptor binding motif,disulfide bond","webmasterTools":{"google-site-verification":"xKDW6DUiGuZ6nwglNeWlVWTgzTtMPzas13ROL63ytTc","msvalidate.01":"5B15601215D876311F84CFEFB0F72F18","miscellaneous":""},"schema":null,"og:locale":"en_US","og:site_name":"LifeTein Peptide Synthesis Blog","og:type":"article","og:title":"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor | LifeTein Peptide Blog2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor","og:description":"A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the \u03b2 sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.The extensive structural analyses have revealed that interactions between SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2","og:url":"https:\/\/www.lifetein.com\/blog\/2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor\/","fb:admins":"233983946638783","og:image":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg","og:image:secure_url":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg","article:tag":["2019-ncov","coronavirus","receptor binding motif","disulfide bond","peptide"],"article:published_time":"2020-02-21T18:29:50+00:00","article:modified_time":"2024-11-17T02:35:01+00:00","article:publisher":"https:\/\/www.facebook.com\/LifeTein-LLC-233983946638783\/","twitter:card":"summary_large_image","twitter:site":"@lifetein","twitter:title":"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor | LifeTein Peptide Blog2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor","twitter:description":"A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the \u03b2 sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.The extensive structural analyses have revealed that interactions between SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2","twitter:creator":"@lifetein","twitter:image":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg"},"aioseo_meta_data":{"post_id":"665","title":"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor | #site_title#post_title","description":"A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the \u03b2 sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.#post_excerpt","keywords":[{"label":"2019-nCoV","value":"2019-nCoV"},{"label":"Coronavirus","value":"Coronavirus"},{"label":"Receptor Binding Motif","value":"Receptor Binding Motif"},{"label":"disulfide bond","value":"disulfide bond"}],"keyphrases":{"focus":{"keyphrase":"RBD, disulfide bond, cyclic peptide, COVID19, Coronavirus, ACE2 Receptor","score":27,"analysis":{"keyphraseInTitle":{"score":3,"maxScore":9,"error":1},"keyphraseInDescription":{"score":3,"maxScore":9,"error":1},"keyphraseLength":{"score":3,"maxScore":9,"error":1,"length":9},"keyphraseInURL":{"score":1,"maxScore":5,"error":1},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInSubHeadings":[],"keyphraseInImageAlt":{"score":3,"maxScore":9,"error":1},"keywordDensity":{"score":0,"type":"low","maxScore":9,"error":1}}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"article","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":true,"twitter_card":"summary_large_image","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"Article","isEnabled":true},"graphs":[]},"schema_type":"none","schema_type_options":"{\"webPage\":{\"webPageType\":\"WebPage\"},\"article\":{\"articleType\":\"BlogPosting\"},\"book\":[],\"course\":[],\"event\":[],\"jobPosting\":[],\"music\":[],\"person\":[],\"product\":[],\"recipe\":[],\"restaurant\":[],\"service\":[],\"software\":[],\"video\":[]}","pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"0","robots_max_videopreview":"0","robots_max_imagepreview":"none","priority":null,"frequency":"default","location":null,"local_seo":null,"seo_analyzer_scan_date":null,"breadcrumb_settings":null,"limit_modified_date":false,"open_ai":"{\"title\":{\"suggestions\":[],\"usage\":0},\"description\":{\"suggestions\":[],\"usage\":0}}","ai":null,"created":"2020-12-04 22:27:30","updated":"2025-06-18 02:55:22"},"aioseo_breadcrumb":"

\n\t\t\tHome<\/a>\n\t\t<\/span>»<\/span>\n\t\t\tPeptide<\/a>\n\t\t<\/span>»<\/span>\n\t\t\t2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/www.lifetein.com\/blog"},{"label":"Peptide","link":"https:\/\/www.lifetein.com\/blog\/category\/peptide_synthesis\/"},{"label":"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor","link":"https:\/\/www.lifetein.com\/blog\/2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor\/"}],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=665"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/665\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/666"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}