{"id":665,"date":"2020-02-21T13:29:50","date_gmt":"2020-02-21T18:29:50","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=665"},"modified":"2024-11-16T21:35:01","modified_gmt":"2024-11-17T02:35:01","slug":"2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor\/","title":{"rendered":"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"577\" src=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/Coronavirus-RBM-1024x577.png\" alt=\"2019-nCoV Coronavirus Receptor -Binding Motif Directly Contacts ACE2 Receptor\" class=\"wp-image-666\" srcset=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/Coronavirus-RBM-1024x577.png 1024w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/Coronavirus-RBM-300x169.png 300w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/Coronavirus-RBM-768x433.png 768w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/Coronavirus-RBM-500x282.png 500w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/Coronavirus-RBM.png 1228w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>2019-nCoV Coronavirus Receptor -Binding Motif<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The extensive structural analyses have revealed that interactions between SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2 as its receptor with much higher affinity (10-20 times higher!) than SARS.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Several critical residues in 2019-nCoV RBM may provide favorable interactions with human ACE2 such as Gln493 and Asn501. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the \u03b2 sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The extensive structural analyses have revealed that interactions between SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. Studies showed that the sequence of 2019-nCoV &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/2019-ncov-coronavirus-receptor-binding-motif-directly-contacts-ace2-receptor\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":666,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-665","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=665"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/665\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/666"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}