{"id":595,"date":"2019-10-05T13:05:49","date_gmt":"2019-10-05T17:05:49","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=595"},"modified":"2024-11-16T21:41:20","modified_gmt":"2024-11-17T02:41:20","slug":"a-click-chemistry-was-reported-about-the-formation-of-azides-from-primary-amines","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/a-click-chemistry-was-reported-about-the-formation-of-azides-from-primary-amines\/","title":{"rendered":"A click chemistry was reported about the formation of azides from primary amines"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"1024\" height=\"895\" src=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2019\/10\/drug-screening-process-1024x895.jpg\" alt=\"\" class=\"wp-image-602\" srcset=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2019\/10\/drug-screening-process-1024x895.jpg 1024w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2019\/10\/drug-screening-process-300x262.jpg 300w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2019\/10\/drug-screening-process-768x672.jpg 768w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2019\/10\/drug-screening-process-343x300.jpg 343w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2019\/10\/drug-screening-process.jpg 1449w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Click chemistry for drug screening<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A click chemistry was reported about the formation of azides from primary amines. This powerful tool enables the reaction of just one equivalent of a simple diazotizing species, and fluorosulfuryl azide (FSO2N3), for the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This method greatly expands the number of accessible azides and 1,2,3-triazoles because the primary amine is one of the most abundant functional groups in small compounds, proteins and antibodies. <\/p>\n\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"formation-of-azides-from-primary-amines\">Formation of Azides From Primary Amines <\/h2>\n\n\n<p class=\"wp-block-paragraph\">The method opens the door for numerous applications in drug screening and discovery. The cell penetration peptides can be easily introduced to conjugate with any azide containing drugs, compounds, antibodies, or proteins. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The cell penetration peptides (CPPs) are capable of delivering biologically active cargo to the cell interior. The desired therapeutic cargo could be attached to a CPP using the copper free click chemistry and then delivered to an intracellular target, thereby overcoming the entry restrictions set by the plasma membrane.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">Peptide Synthesis Home Page<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our Services:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/peptide-product\/covid19products-c-64.html\" target=\"_blank\" rel=\"noreferrer noopener\">COVID-19 Services &amp; Products<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/antibody_services.html\" target=\"_blank\" rel=\"noreferrer noopener\">Custom Antibody Services<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/Rush-Peptide-Synthesis-Service.html\" target=\"_blank\" rel=\"noreferrer noopener\">Rush Peptide Synthesis<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/Peptide-Nucleic-Acid.html\" target=\"_blank\" rel=\"noreferrer noopener\">Peptide Nucleic Acids (PNAs)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/peptide_synthesis_services.html\" target=\"_blank\" rel=\"noreferrer noopener\">Custom Peptide Synthesis Services<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/protein-expression-service.html\" target=\"_blank\" rel=\"noreferrer noopener\">Gene Synthesis Service<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/custom_chemical_synthesis.html\" target=\"_blank\" rel=\"noreferrer noopener\">Custom Chemical Synthesis<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Other Posts:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/blog\/the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets\/\" target=\"_blank\" rel=\"noreferrer noopener\">Smaller Ions Stabilize \u03b2-sheets<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/blog\/lifeteins-synthetic-scorpion-toxin-peptides-helped-scientists-unravel-chronic-pain-mechanisms\/\" target=\"_blank\" rel=\"noopener\" title=\"\">Synthetic Scorpion Toxin Peptides for Chronic Pain<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><meta charset=\"utf-8\"\/><a href=\"https:\/\/www.lifetein.com\/blog\/the-nobel-prize-in-physiology-or-medicine-2019-was-awarded-jointly-to-william-g-kaelin-jr-sir-peter-j-ratcliffe-and-gregg-l-semenza\/\" target=\"_blank\" rel=\"noreferrer noopener\">LifeTein Synthesized a Key Peptide That Played a Role in the Nobel Prize in Physiology or Medicine 2019<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A click chemistry was reported about the formation of azides from primary amines. This powerful tool enables the reaction of just one equivalent of a simple diazotizing species, and fluorosulfuryl azide (FSO2N3), for the preparation of over 1,200 azides on &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/a-click-chemistry-was-reported-about-the-formation-of-azides-from-primary-amines\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":602,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-595","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=595"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/595\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/602"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}