{"id":576,"date":"2019-07-31T12:33:07","date_gmt":"2019-07-31T16:33:07","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=576"},"modified":"2024-11-16T21:43:06","modified_gmt":"2024-11-17T02:43:06","slug":"the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets\/","title":{"rendered":"Ionic Magic: Small Ions Transform Peptides into Stable \u03b2-Sheets"},"content":{"rendered":"\n
\n
\"NaF
The smaller ions (F- and Cl-, 50mM NaF and NaCl solutions) tend to stabilize \u03b2-sheets<\/figcaption><\/figure>\n<\/figure>\n\n\n\n

Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues), others are formed by extended-strands.<\/p>\n\n\n\n

Smaller Ions Stabilize \u03b2-sheets<\/h2>\n\n\n\n

The strongly-hydrated ions (F- and Cl-) are more attracted to the positively charged lysine residues on the surface of the peptide nanofiber. When peptide residues form \u03b2-sheets, an F- or Cl- ion forms a salt bridge between the side chains of lysine residues from two neighboring peptide amphiphile chains. The salt bridge stabilizes the peptide by bringing the backbones closer, resulting in a transition from random coil to extended \u03b2-sheets structures. The smaller ions (F- and Cl-, 50mM NaF and NaCl solutions) tend to stabilize \u03b2-sheets slightly better compared to the larger ions (I-, Br-).<\/p>\n\n\n\n

So, the self-assembly of peptide amphiphiles into supramolecular nanofibers can be regulated by modifying the salt solution. <\/p>\n\n\n\n

Reference: doi.org\/10.1021\/acs.jpcb.9b05532<\/p>\n","protected":false},"excerpt":{"rendered":"

Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues), others are formed by extended-strands. Smaller Ions … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":577,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-576","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=576"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/576\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/577"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}