{"id":576,"date":"2019-07-31T12:33:07","date_gmt":"2019-07-31T16:33:07","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=576"},"modified":"2024-11-16T21:43:06","modified_gmt":"2024-11-17T02:43:06","slug":"the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets\/","title":{"rendered":"Ionic Magic: Small Ions Transform Peptides into Stable \u03b2-Sheets"},"content":{"rendered":"\n
\n
\"NaF
The smaller ions (F- and Cl-, 50mM NaF and NaCl solutions) tend to stabilize \u03b2-sheets<\/figcaption><\/figure>\n<\/figure>\n\n\n\n

Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues), others are formed by extended-strands.<\/p>\n\n\n\n

Smaller Ions Stabilize \u03b2-sheets<\/h2>\n\n\n\n

The strongly-hydrated ions (F- and Cl-) are more attracted to the positively charged lysine residues on the surface of the peptide nanofiber. When peptide residues form \u03b2-sheets, an F- or Cl- ion forms a salt bridge between the side chains of lysine residues from two neighboring peptide amphiphile chains. The salt bridge stabilizes the peptide by bringing the backbones closer, resulting in a transition from random coil to extended \u03b2-sheets structures. The smaller ions (F- and Cl-, 50mM NaF and NaCl solutions) tend to stabilize \u03b2-sheets slightly better compared to the larger ions (I-, Br-).<\/p>\n\n\n\n

So, the self-assembly of peptide amphiphiles into supramolecular nanofibers can be regulated by modifying the salt solution. <\/p>\n\n\n\n

Reference: doi.org\/10.1021\/acs.jpcb.9b05532<\/p>\n","protected":false},"excerpt":{"rendered":"

Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues), others are formed by extended-strands. Smaller Ions … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":577,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-576","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\n","aioseo_head_json":{"title":"The smaller ions tend to stabilize \u03b2-sheets formed by peptides","description":"Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues) others are formed by extended \u03b2-strand","canonical_url":"https:\/\/www.lifetein.com\/blog\/the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets\/","robots":"max-image-preview:large","keywords":"\u03b2-strands,\u03b2-sheet,peptide","webmasterTools":{"google-site-verification":"xKDW6DUiGuZ6nwglNeWlVWTgzTtMPzas13ROL63ytTc","msvalidate.01":"5B15601215D876311F84CFEFB0F72F18","miscellaneous":""},"schema":null,"og:locale":"en_US","og:site_name":"LifeTein Peptide Synthesis Blog","og:type":"article","og:title":"The smaller ions tend to stabilize \u03b2-sheets formed by peptides","og:description":"Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues) others are formed by extended \u03b2-strand","og:url":"https:\/\/www.lifetein.com\/blog\/the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets\/","fb:admins":"233983946638783","og:image":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg","og:image:secure_url":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg","article:tag":["\u03b2-strands","\u03b2-sheet","peptide"],"article:published_time":"2019-07-31T16:33:07+00:00","article:modified_time":"2024-11-17T02:43:06+00:00","article:publisher":"https:\/\/www.facebook.com\/LifeTein-LLC-233983946638783\/","twitter:card":"summary_large_image","twitter:site":"@lifetein","twitter:title":"The smaller ions tend to stabilize \u03b2-sheets formed by peptides","twitter:description":"Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues) others are formed by extended \u03b2-strand","twitter:creator":"@lifetein","twitter:image":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg"},"aioseo_meta_data":{"post_id":"576","title":"The smaller ions tend to stabilize \u03b2-sheets formed by peptides","description":"Peptide amphiphiles are composed of hydrophobic alkyl tails and peptide regions designed to self-assemble into cylindrical supramolecular nanofibers in solution. While hydrogen bonds form some \u03b2-sheets between short \u03b2-strands (2 or 3 residues) others are formed by extended \u03b2-strand","keywords":[{"label":"\u03b2-strands","value":"\u03b2-strands"},{"label":"\u03b2-sheet","value":"\u03b2-sheet"},{"label":"peptide","value":"peptide"}],"keyphrases":{"focus":{"keyphrase":"peptide beta-sheets","score":37,"analysis":{"keyphraseInTitle":{"score":3,"maxScore":9,"error":1},"keyphraseInDescription":{"score":3,"maxScore":9,"error":1},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":2},"keyphraseInURL":{"score":1,"maxScore":5,"error":1},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInSubHeadings":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":{"score":3,"maxScore":9,"error":1},"keywordDensity":{"score":0,"type":"low","maxScore":9,"error":1}}},"additional":[{"keyphrase":"peptide synthesis","score":40,"analysis":{"keyphraseInDescription":{"score":3,"maxScore":9,"error":1},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":2},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":{"score":3,"maxScore":9,"error":1},"keywordDensity":{"score":0,"type":"low","maxScore":9,"error":1}}}]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"article","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":true,"twitter_card":"summary_large_image","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":{"id":"aioseo-article-633df08ac33c0","slug":"article","graphName":"Article","label":"Article","properties":{"type":"BlogPosting","name":"#post_title","headline":"#post_title","description":"#post_excerpt","image":"","keywords":"","author":{"name":"#author_name","url":"#author_url"},"dates":{"include":true,"datePublished":"","dateModified":""}}},"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"Article","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":"{\"article\":{\"articleType\":\"BlogPosting\"},\"course\":{\"name\":\"\",\"description\":\"\",\"provider\":\"\"},\"faq\":{\"pages\":[]},\"product\":{\"reviews\":[]},\"recipe\":{\"ingredients\":[],\"instructions\":[],\"keywords\":[]},\"software\":{\"reviews\":[],\"operatingSystems\":[]},\"webPage\":{\"webPageType\":\"WebPage\"}}","pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"none","priority":null,"frequency":"default","location":null,"local_seo":null,"seo_analyzer_scan_date":null,"breadcrumb_settings":null,"limit_modified_date":false,"open_ai":"{\"title\":{\"suggestions\":[],\"usage\":0},\"description\":{\"suggestions\":[],\"usage\":0}}","ai":null,"created":"2020-12-04 22:27:30","updated":"2025-06-18 02:51:20"},"aioseo_breadcrumb":"

\n\t\t\tHome<\/a>\n\t\t<\/span>»<\/span>\n\t\t\tPeptide<\/a>\n\t\t<\/span>»<\/span>\n\t\t\tIonic Magic: Small Ions Transform Peptides into Stable \u03b2-Sheets\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/www.lifetein.com\/blog"},{"label":"Peptide","link":"https:\/\/www.lifetein.com\/blog\/category\/peptide_synthesis\/"},{"label":"Ionic Magic: Small Ions Transform Peptides into Stable \u03b2-Sheets","link":"https:\/\/www.lifetein.com\/blog\/the-smaller-ions-f-and-cl-50mm-naf-and-nacl-solutions-tend-to-stabilize-%ce%b2-sheets\/"}],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=576"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/576\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/577"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}