{"id":377,"date":"2018-01-30T16:23:37","date_gmt":"2018-01-30T21:23:37","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=377"},"modified":"2024-11-16T22:23:59","modified_gmt":"2024-11-17T03:23:59","slug":"how-hiv-1-integrase-contributes-to-virion-morphogenesis","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/how-hiv-1-integrase-contributes-to-virion-morphogenesis\/","title":{"rendered":"How HIV-1 integrase contributes to virion morphogenesis?"},"content":{"rendered":"<p>It was found that the HIV-1 Integrase binds the Viral RNA genome and is essential during Virion Morphogenesis. The L50 Peptide: Cyclo-(-Arg-Val-Arg-Thr-Arg-Gly-LysArg-Arg-Ile-Arg-Arg-DPro-Pro-) was synthesized by LifeTein and used for the inhibition assays.\u00a0The L50 is a Tat-derived peptide sequence, which selectively engages both the loop and 3-nt bulge<br \/>but not the double-stranded stem of the transactivation response. The TAT-derived peptide is a well-defined cell penetration peptide.<\/p>\n<h2 style=\"text-align: center;\">HIV-1 Integrase Binds the Viral RNA genome<\/h2>\n<div id=\"attachment_424\" style=\"width: 310px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-424\" class=\"wp-image-424 size-medium\" src=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2018\/01\/Screen-Shot-2018-01-30-at-4.21.49-PM-1-300x271.png\" alt=\"Cell Penetration Peptides\" width=\"300\" height=\"271\" srcset=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2018\/01\/Screen-Shot-2018-01-30-at-4.21.49-PM-1-300x271.png 300w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2018\/01\/Screen-Shot-2018-01-30-at-4.21.49-PM-1-332x300.png 332w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2018\/01\/Screen-Shot-2018-01-30-at-4.21.49-PM-1.png 728w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><p id=\"caption-attachment-424\" class=\"wp-caption-text\">Cell Penetration Peptides<\/p><\/div>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>It was found that the HIV-1 Integrase binds the Viral RNA genome and is essential during Virion Morphogenesis. The L50 Peptide: Cyclo-(-Arg-Val-Arg-Thr-Arg-Gly-LysArg-Arg-Ile-Arg-Arg-DPro-Pro-) was synthesized by LifeTein and used for the inhibition assays.\u00a0The L50 is a Tat-derived peptide sequence, which selectively &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/how-hiv-1-integrase-contributes-to-virion-morphogenesis\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":515,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[69,68],"class_list":["post-377","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis","tag-cell-penetration-peptide","tag-tat-derived-peptide"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=377"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/377\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/515"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}