{"id":360,"date":"2017-09-15T12:07:33","date_gmt":"2017-09-15T16:07:33","guid":{"rendered":"https:\/\/www.lifetein.com\/blog\/?p=360"},"modified":"2024-11-16T22:25:44","modified_gmt":"2024-11-17T03:25:44","slug":"how-do-peptides-fold","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/how-do-peptides-fold\/","title":{"rendered":"How do peptides fold?"},"content":{"rendered":"<div id=\"attachment_361\" style=\"width: 310px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-361\" class=\"size-medium wp-image-361\" src=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2017\/09\/short-peptide-folding-300x226.png\" alt=\"peptide fold\" width=\"300\" height=\"226\" srcset=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2017\/09\/short-peptide-folding-300x226.png 300w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2017\/09\/short-peptide-folding.png 357w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><p id=\"caption-attachment-361\" class=\"wp-caption-text\">Short Peptide Folding<\/p><\/div>\n<p>How does the amino acid sequence of a protein chain determine and maintain its 3D folded state? How do small proteins fold?<\/p>\n<h2 style=\"text-align: center;\">Short Peptide Folding<\/h2>\n<p>Many small proteins or miniproteins are peptides shorter than 40-50 residues with stable folding that contain secondary structure elements such as alpha helices and beta strands.<\/p>\n<p>An autonomously folding, 35-residue, thermostable subdomain (HP36) of the villain headpiece is the smallest folded domain of a naturally occurring protein. Polypeptides simplify the protein-folding problem. They allow in-depth examinations of sequence-structure-stability relationships without using the complex larger proteins.<\/p>\n<p>In this recent study, Rocklin et al. designed sequences intended to fold into desired structures. The novel proteins may be helpful in bioengineering or pharmacological applications.<\/p>\n<p>Check the paper from here: https:\/\/goo.gl\/Tregb7<\/p>\n<p>http:\/\/science.sciencemag.org\/content\/357\/6347\/168<\/p>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>How does the amino acid sequence of a protein chain determine and maintain its 3D folded state? How do small proteins fold? Short Peptide Folding Many small proteins or miniproteins are peptides shorter than 40-50 residues with stable folding that &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/how-do-peptides-fold\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":1910,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[40,52,34,7,53],"class_list":["post-360","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis","tag-custom-peptide-synthesis-service","tag-peptide-refolding","tag-peptide-stability","tag-peptides","tag-protein-refolding"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=360"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/360\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/1910"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}