{"id":296,"date":"2016-01-14T10:42:48","date_gmt":"2016-01-14T15:42:48","guid":{"rendered":"http:\/\/www.lifetein.com\/blog\/?p=296"},"modified":"2024-11-16T22:29:42","modified_gmt":"2024-11-17T03:29:42","slug":"how-does-bird-2-peptide-kill-b-cell-lymphoma","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/how-does-bird-2-peptide-kill-b-cell-lymphoma\/","title":{"rendered":"How BIRD-2 Peptide Takes Down B-Cell Lymphoma?"},"content":{"rendered":"<p>The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their primary survival mechanism by binding to IP3R2 on the endoplasmic reticulum (ER).\u00a0 In this study, a cell-penetrating version of the BIRD-2 peptide (Bcl-2\/IP3R Disrupter-2 peptide with a TAT sequence) made by LifeTein was used to break up the complex formed by Bcl-2 and IP3R2 in human diffuse large B-cell lymphoma (DLBCL) cells. Ca<sup>2+<\/sup> signaling-related events are suggested to be the killing mechanism of BIRD-2 peptide on DLBCL cells.<\/p>\n<p><a href=\"https:\/\/www.lifetein.com\/peptide-product\/bird2-peptide-p-10269.html\">BIRD-2<\/a>, a peptide that explicitly disrupts the Bcl2\/IP3R complex, was utilized to further verify the mitochondrial Ca<sup>2+<\/sup> regulatory mechanism via the Bmal1-Bcl2\/IP3R signaling pathway. It was found that <strong>BIRD-2 aggravated mitochondrial Ca<\/strong><sup><strong>2+<\/strong><\/sup>\u00a0<strong>overload and apoptosis\u00a0<em>in vitro.<\/em><\/strong><\/p>\n<p>Purchase BIRD-2 peptide now. Click <a href=\"https:\/\/www.lifetein.com\/peptide-product\/bird2-peptide-p-10269.html\">here<\/a>.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6214954\/\">BIRD-2 peptide (sequence: RKKRRQRRRGGNVYTEIKCNSLLPLAAIVRV) was purchased from LifeTein (South Plainfield, NJ, USA) with a purity of &gt;85%.<\/a><\/p>\n<h2 style=\"text-align: center;\">Bird-2 Peptides &amp; B-Cell Lymphoma<\/h2>\n<p><strong>Reference:<\/strong><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213231723001891#appsec1\">BIRD-2 peptide (LifeTein, USA), specifically disrupting the Bcl2\/IP3R complex, was used in HGHP-treated H9c2 cells for 12\u202fh (20\u202f\u03bcM)<\/a><\/p>\n<p><strong><a href=\"https:\/\/journals.open.tudelft.nl\/sure\/article\/view\/1071\">Inhibiting Bcl-2 via its BH4 domain in DLBCL cancers to provoke pro-apoptotic Ca<sup>2+<\/sup> signaling<\/a><\/strong><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0143416020301755\">BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax\/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening <\/a><\/p>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their primary survival mechanism by binding to IP3R2 on the endoplasmic reticulum (ER).\u00a0 In this study, a cell-penetrating version of the BIRD-2 peptide (Bcl-2\/IP3R Disrupter-2 peptide with a TAT &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/how-does-bird-2-peptide-kill-b-cell-lymphoma\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":1920,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[14,3,11,27],"class_list":["post-296","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis","tag-cancer-peptide","tag-cell-penetrating-peptide-synthesis","tag-cell-penetrating-peptides","tag-peptide"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=296"}],"version-history":[{"count":0,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/posts\/296\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media\/1920"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/categories?post=296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/tags?post=296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}