{"id":296,"date":"2016-01-14T10:42:48","date_gmt":"2016-01-14T15:42:48","guid":{"rendered":"http:\/\/www.lifetein.com\/blog\/?p=296"},"modified":"2024-11-16T22:29:42","modified_gmt":"2024-11-17T03:29:42","slug":"how-does-bird-2-peptide-kill-b-cell-lymphoma","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/how-does-bird-2-peptide-kill-b-cell-lymphoma\/","title":{"rendered":"How BIRD-2 Peptide Takes Down B-Cell Lymphoma?"},"content":{"rendered":"

The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their primary survival mechanism by binding to IP3R2 on the endoplasmic reticulum (ER).\u00a0 In this study, a cell-penetrating version of the BIRD-2 peptide (Bcl-2\/IP3R Disrupter-2 peptide with a TAT sequence) made by LifeTein was used to break up the complex formed by Bcl-2 and IP3R2 in human diffuse large B-cell lymphoma (DLBCL) cells. Ca2+<\/sup> signaling-related events are suggested to be the killing mechanism of BIRD-2 peptide on DLBCL cells.<\/p>\n

BIRD-2<\/a>, a peptide that explicitly disrupts the Bcl2\/IP3R complex, was utilized to further verify the mitochondrial Ca2+<\/sup> regulatory mechanism via the Bmal1-Bcl2\/IP3R signaling pathway. It was found that BIRD-2 aggravated mitochondrial Ca<\/strong>2+<\/strong><\/sup>\u00a0overload and apoptosis\u00a0in vitro.<\/em><\/strong><\/p>\n

Purchase BIRD-2 peptide now. Click here<\/a>.<\/p>\n

BIRD-2 peptide (sequence: RKKRRQRRRGGNVYTEIKCNSLLPLAAIVRV) was purchased from LifeTein (South Plainfield, NJ, USA) with a purity of >85%.<\/a><\/p>\n

Bird-2 Peptides & B-Cell Lymphoma<\/h2>\n

Reference:<\/strong><\/p>\n

BIRD-2 peptide (LifeTein, USA), specifically disrupting the Bcl2\/IP3R complex, was used in HGHP-treated H9c2 cells for 12\u202fh (20\u202f\u03bcM)<\/a><\/p>\n

Inhibiting Bcl-2 via its BH4 domain in DLBCL cancers to provoke pro-apoptotic Ca2+<\/sup> signaling<\/a><\/strong><\/p>\n

BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax\/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening <\/a><\/p>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their primary survival mechanism by binding to IP3R2 on the endoplasmic reticulum (ER).\u00a0 In this study, a cell-penetrating version of the BIRD-2 peptide (Bcl-2\/IP3R Disrupter-2 peptide with a TAT … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":1920,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[4],"tags":[14,3,11,27],"class_list":["post-296","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis","tag-cancer-peptide","tag-cell-penetrating-peptide-synthesis","tag-cell-penetrating-peptides","tag-peptide"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\n","aioseo_head_json":{"title":"How does BIRD-2 peptide kill B-cell lymphoma? | LifeTein Peptide Blog","description":"The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their main survival mechanism by binding to IP3R2 on endoplasmic reticulum (ER). In this study, a cell-penetrating version of BIRD-2 peptide (Bcl-2\/IP3R Disrupter-2 peptide with a TAT sequence) made by LifeTein was used to break up the complex formed by Bcl-2 and IP3R2 in human diffuse large B-cell lymphoma (DLBCL) cells.","canonical_url":"https:\/\/www.lifetein.com\/blog\/how-does-bird-2-peptide-kill-b-cell-lymphoma\/","robots":"max-image-preview:large","keywords":"cancer peptide,cell penetrating peptide,peptide synthesis,cell penetrating peptide synthesis,cell penetrating peptides,peptide","webmasterTools":{"google-site-verification":"xKDW6DUiGuZ6nwglNeWlVWTgzTtMPzas13ROL63ytTc","msvalidate.01":"5B15601215D876311F84CFEFB0F72F18","miscellaneous":""},"schema":null,"og:locale":"en_US","og:site_name":"LifeTein Peptide Synthesis Blog","og:type":"activity","og:title":"How does BIRD-2 peptide kill B-cell lymphoma? | LifeTein Peptide Blog","og:description":"The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their main survival mechanism by binding to IP3R2 on endoplasmic reticulum (ER). 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In this study, a cell-penetrating version of BIRD-2 peptide (Bcl-2\/IP3R Disrupter-2 peptide with a TAT sequence) made by LifeTein was used to break up the complex formed by Bcl-2 and IP3R2 in human diffuse large B-cell lymphoma (DLBCL) cells.","twitter:creator":"@lifetein","twitter:image":"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2020\/02\/LifeTein-Blog1-2-scaled.jpg"},"aioseo_meta_data":{"post_id":"296","title":"How does BIRD-2 peptide kill B-cell lymphoma? | #site_title","description":"The anti-apoptotic factor Bcl-2 is over-expressed in B-cell lymphoma cells as their main survival mechanism by binding to IP3R2 on endoplasmic reticulum (ER).\u00a0 In this study, a cell-penetrating version of BIRD-2 peptide (Bcl-2\/IP3R Disrupter-2 peptide with a TAT sequence) made by LifeTein was used to break up the complex formed by Bcl-2 and IP3R2 in human diffuse large B-cell lymphoma (DLBCL) cells.","keywords":[{"label":"cancer peptide","value":"cancer peptide"},{"label":"cell penetrating peptide","value":"cell penetrating peptide"},{"label":"peptide synthesis","value":"peptide synthesis"}],"keyphrases":{"focus":{"keyphrase":"BIRD-2 peptide","score":75,"analysis":{"keyphraseInTitle":{"score":9,"maxScore":9,"error":0},"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":2},"keyphraseInURL":{"score":5,"maxScore":5,"error":0},"keyphraseInIntroduction":{"score":9,"maxScore":9,"error":0},"keyphraseInSubHeadings":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":[],"keywordDensity":{"type":"high","score":0,"maxScore":9,"error":1}}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"activity","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":true,"twitter_card":"summary","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":{"id":"aioseo-article-633cec8d8d388","slug":"article","graphName":"Article","label":"Article","properties":{"type":"BlogPosting","name":"#post_title","headline":"#post_title","description":"#post_excerpt","image":"","keywords":"","author":{"name":"#author_name","url":"#author_url"},"dates":{"include":true,"datePublished":"","dateModified":""}}},"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"Article","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":"{\"article\":{\"articleType\":\"BlogPosting\"},\"course\":{\"name\":\"\",\"description\":\"\",\"provider\":\"\"},\"faq\":{\"pages\":[]},\"product\":{\"reviews\":[]},\"recipe\":{\"ingredients\":[],\"instructions\":[],\"keywords\":[]},\"software\":{\"reviews\":[],\"operatingSystems\":[]},\"webPage\":{\"webPageType\":\"WebPage\"}}","pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"none","priority":0,"frequency":"default","location":null,"local_seo":null,"seo_analyzer_scan_date":null,"breadcrumb_settings":null,"limit_modified_date":false,"open_ai":"{\"title\":{\"suggestions\":[],\"usage\":0},\"description\":{\"suggestions\":[],\"usage\":0}}","ai":null,"created":"2020-12-04 22:27:49","updated":"2025-06-18 02:43:16","focus_keyword":"BIRD-2 peptide","additional_keywords":null,"truseo_locale":null},"aioseo_breadcrumb":"

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