{"id":126,"date":"2012-06-13T13:20:01","date_gmt":"2012-06-13T17:20:01","guid":{"rendered":"http:\/\/www.lifetein.com\/blog\/?p=126"},"modified":"2024-11-16T22:38:05","modified_gmt":"2024-11-17T03:38:05","slug":"the-structural-basis-of-peptide-protein-binding-strategies","status":"publish","type":"post","link":"https:\/\/www.lifetein.com\/blog\/the-structural-basis-of-peptide-protein-binding-strategies\/","title":{"rendered":"The Structural Basis of Peptide-Protein Binding Strategies"},"content":{"rendered":"<div id=\"attachment_128\" style=\"width: 310px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/www.lifetein.com\/blog\/the-structural-basis-of-peptide-protein-binding-strategies\/peptide-protein-binding\/\" rel=\"attachment wp-att-128\"><img decoding=\"async\" aria-describedby=\"caption-attachment-128\" class=\"size-medium wp-image-128  \" title=\"peptide protein binding strategy\" src=\"http:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2012\/06\/peptide-protein-binding-300x214.jpg\" alt=\"peptide protein binding strategy\" width=\"300\" height=\"214\" srcset=\"https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2012\/06\/peptide-protein-binding-300x214.jpg 300w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2012\/06\/peptide-protein-binding-418x300.jpg 418w, https:\/\/www.lifetein.com\/blog\/wp-content\/uploads\/2012\/06\/peptide-protein-binding.jpg 670w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-128\" class=\"wp-caption-text\">Peptide protein binding strategies: Structure, Volume 18, Issue 2, 188-199, 10 February 2010<\/p><\/div>\n<h2 style=\"text-align: center;\">Peptide-Protein Binding<\/h2>\n<p><strong>Highlights<\/strong><\/p>\n<ul>\n<li>After binding its partners, most peptides do not introduce any\u00a0conformational changes<\/li>\n<li>The interfaces of peptide-protein have more hydrogen bonds<\/li>\n<li>The\u00a0peptide hotspots are important for the binding<\/li>\n<li>Peptides prefer\u00a0to bind in the largest pockets on the protein surface<\/li>\n<\/ul>\n<p>LifeTein is pleased to offer a free, comprehensive web-based\u00a0<a id=\"\" href=\"http:\/\/lifetein.com\/peptide-analysis-tool.html\" target=\"_blank\" rel=\"noopener\">peptide analysis tool<\/a>.\u00a0This tool will allow your research team to overcome common difficulties inherent in protein analysis and peptide antigen design.<\/p>\n<div>\u00a0<\/div>\n<div>Try it now at\u00a0<a id=\"\" href=\"http:\/\/lifetein.com\/peptide-analysis-tool.html\" target=\"_blank\" rel=\"noopener\">http:\/\/lifetein.com\/peptide-analysis-tool.html<\/a>.<\/div>\n<div>\u00a0<\/div>\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">Peptide Synthesis Home Page<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our Services:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/peptide-product\/covid19products-c-64.html\" target=\"_blank\" rel=\"noreferrer noopener\">COVID-19 Services &amp; Products<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/antibody_services.html\" target=\"_blank\" rel=\"noreferrer noopener\">Custom Antibody Services<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/Rush-Peptide-Synthesis-Service.html\" target=\"_blank\" rel=\"noreferrer noopener\">Rush Peptide Synthesis<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/Peptide-Nucleic-Acid.html\" target=\"_blank\" rel=\"noreferrer noopener\">Peptide Nucleic Acids (PNAs)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/peptide_synthesis_services.html\" target=\"_blank\" rel=\"noreferrer noopener\">Custom Peptide Synthesis Services<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/protein-expression-service.html\" target=\"_blank\" rel=\"noreferrer noopener\">Gene Synthesis Service<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/custom_chemical_synthesis.html\" target=\"_blank\" rel=\"noreferrer noopener\">Custom Chemical Synthesis<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Other Posts:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.lifetein.com\/blog\/lifetein-peptide-cited-in-cell\/\">LifeTein Peptide Cited in Cell<\/a>\n\n<a href=\"https:\/\/www.lifetein.com\/blog\/phospho-specific-antibodies-lifetein-published-nature\/\">Phospho-specific antibodies by LifeTein published in Nature<\/a>\n\n<a href=\"https:\/\/www.lifetein.com\/blog\/synthesis-of-multiple-antigenic-peptidesstrategies-and-limitations\/\">Synthesis of multiple antigenic peptides: strategies and limitations<\/a>\n\n<a href=\"https:\/\/www.lifetein.com\/blog\/synthetic-peptides-used-for-indirect-elisa\/\">Synthetic Peptides Used for indirect ELISA<\/a><\/p>\n\n\n","protected":false},"excerpt":{"rendered":"<p>Peptide-Protein Binding Highlights After binding its partners, most peptides do not introduce any\u00a0conformational changes The interfaces of peptide-protein have more hydrogen bonds The\u00a0peptide hotspots are important for the binding Peptides prefer\u00a0to bind in the largest pockets on the protein surface &hellip; <a href=\"https:\/\/www.lifetein.com\/blog\/the-structural-basis-of-peptide-protein-binding-strategies\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":1886,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[23,24],"class_list":["post-126","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptide_synthesis","tag-peptide-protein-interaction","tag-peptide-protein-binding"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Peptide-protein interactions are the key processes for signal transduction and protein trafficking. 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22:27:49","updated":"2025-06-18 02:39:14"},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.lifetein.com\/blog\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.lifetein.com\/blog\/category\/peptide_synthesis\/\" title=\"Peptide\">Peptide<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tThe Structural Basis of Peptide-Protein Binding Strategies\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/www.lifetein.com\/blog"},{"label":"Peptide","link":"https:\/\/www.lifetein.com\/blog\/category\/peptide_synthesis\/"},{"label":"The Structural Basis of Peptide-Protein Binding 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