{"id":2767,"date":"2026-02-27T22:13:48","date_gmt":"2026-02-28T03:13:48","guid":{"rendered":"https:\/\/lifetein.com\/blog\/docs\/improved-identification-of-neoantigen-reactive-t-cells-targeting-both-unique-and-common-oncogenes-for-personalized-cancer-immunotherapy\/"},"modified":"2026-03-02T10:56:16","modified_gmt":"2026-03-02T15:56:16","password":"","slug":"improved-identification-of-neoantigen-reactive-t-cells-targeting-both-unique-and-common-oncogenes-for-personalized-cancer-immunotherapy","status":"publish","type":"docs","link":"https:\/\/www.lifetein.com\/blog\/docs\/improved-identification-of-neoantigen-reactive-t-cells-targeting-both-unique-and-common-oncogenes-for-personalized-cancer-immunotherapy\/","title":{"rendered":"Improved identification of neoantigen-reactive T cells targeting both unique and common oncogenes for personalized cancer immunotherapy"},"content":{"rendered":"

Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) that target neoantigens can cause tumor regression in certain patients with metastatic epithelial cancer. However, identifying and utilizing neoantigen-reactive T cells for treatment remains challenging, and it is unclear if current detection methods miss clinically significant neoantigen reactivities. To address this, scientists explored whether enriching for T cells expressing PD-1 and\/or activation markers, followed by microwell culture to prevent overgrowth of nonreactive T cells, could improve the detection of neoantigen-reactive TILs.<\/p>\n

This linear peptide is suggested: MTEYKLVVVGAVGVGKSALTIQLI<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) that target neoantigens can cause tumor regression in certain patients with metastatic epithelial cancer. However, identifying and utilizing neoantigen-reactive T cells for treatment remains challenging, and it is unclear if current detection … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"doc_category":[331],"doc_tag":[],"class_list":["post-2767","docs","type-docs","status-publish","hentry","doc_category-technical-protocols"],"aioseo_notices":[],"year_month":"2026-04","word_count":86,"total_views":0,"reactions":{"happy":0,"normal":0,"sad":0},"author_info":{"name":"lifetein","author_nicename":"new_blog","author_url":"https:\/\/www.lifetein.com\/blog\/author\/new_blog\/"},"doc_category_info":[{"term_name":"Technical Protocols","term_url":"https:\/\/www.lifetein.com\/blog\/docs-category\/technical-protocols\/"}],"doc_tag_info":[],"_links":{"self":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/docs\/2767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/docs"}],"about":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/types\/docs"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/comments?post=2767"}],"version-history":[{"count":2,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/docs\/2767\/revisions"}],"predecessor-version":[{"id":2814,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/docs\/2767\/revisions\/2814"}],"wp:attachment":[{"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/media?parent=2767"}],"wp:term":[{"taxonomy":"doc_category","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/doc_category?post=2767"},{"taxonomy":"doc_tag","embeddable":true,"href":"https:\/\/www.lifetein.com\/blog\/wp-json\/wp\/v2\/doc_tag?post=2767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}