Recombinant TGF β1 (Transforming Growth Factor-β1 )

Catalog Number:
LT13511
Quantity:
1 MG
Category:
Recombinant TGF β1 (Transforming Growth Factor-β1 )
Listing Name:
Cartilage-inducing factor, Differentiation inhibiting factor
Species:
Human
Description:
Human Transforming Growth Factor-b1 (TGF-b1) is a member of a superfamily of homologous, disulfide-linked, homo-dimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. TGF-β1 is synthesized in cells as a 390-amino acid precursor. The protein undergoes a number of intracellular processing steps including proteolytic digestion of the precursor yielding two products that assemble into dimers. The 65–75 kDa N-terminal cleavage product corresponds to the latency-associated peptide (LAP), and the 25-kDa C-terminal portion of the precursor constitutes
the mature TGF- β1.
Amino Acid Sequence:
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
Molecular Weight:
25 kDA, glycosylated
Expression System:
Chinese Hamster Ovary cells
Purity:
>95%, Determined by SDS‐PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level:
Endotoxin Level < 1.0 EU per 1 μg of the protein by the LAL method
Formulation:
Sterile filtered 0.22 um filter in 20 mM TRIS*HCl buffer pH 7.2. Activated in vitro at pH below 3.5 and over 12.5.
Biological Activity:
The ED50 is typically 20-60 ng/mL before activation and 0.1‑1 ng/mL after activation.
Recombinant Protein Transforming-Growth-Factor
Storage:
‐20°C to ‐80°C
For research purposes only! Not for human or animal therapeutic or diagnostic use.
  • 4 Units in Stock

$3,575.00

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