2019 Coronavirus SARS-CoV-2 Receptor Binding Motif

$990.00

coronavirus

Researchers from around the world have asked LifeTein for providing peptides to develop vaccines targeting the Wuhan coronavirus (2019-nCoV) or SARS-CoV-2.

LifeTein synthesized the receptor-binding motif (RBM) in 6 days. This is part of the receptor-binding domain (RBD). It is a critical determinant of virus-receptor interaction and thus of viral host range and tropism. The RBD also includes important viral-neutralizing epitopes (21–23), and it may be sufficient to raise a protective antibody response in inoculated animals.

A total of nine cysteine residues are found in the RBD, six of which forming three pairs of disulfide bonds. Among these three pairs, two are in the core (Cys336-Cys361 and Cys379-Cys432) to help stabilize the beta sheet structure while the remaining one (Cys480-Cys488) connects loops in the distal end of the RBM.

Studies showed that the sequence of 2019-nCoV coronavirus RBD, including its receptor -binding motif (RBM) that directly contacts ACE2 and uses ACE2 as its receptor with much higher affinity (10-20 times higher!) than SARS.

Peptide sequence: SNNLDSKVGG NYNYLYRLFR KSNLKPFERD ISTEIYQAGS TPCNGVEGFN CYFPLQSYGF QPTNGVGYQ

Modifications: N-Terminal: Biotin Labeling, Disulfide Bridge: Cys480-Cys488

Quantity: 1mg

Formula: C361H528N96O109S3

Molecular Weight: 8052.94

Download Data File:download pdf data sheet

Purity: >99% by HPLC

download pdf data sheet

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