Amino acid composition of cell-penetrating peptides (CPPs)

Cell-penetrating peptides (CPPs) such as the HIV TAT peptides are able to enter cells by direct translocation and endocytosis. Click here to see details about the CPP: http://lifetein.com/Cell_Penetrating_Peptides.html

About Cell-Penetrating Peptides

cell penetrating peptide entry mechanism

Cell Penetrating Peptides

The following table shows a selection of currently known CPPs, their origins, and sequences.
Name

Origin

Sequence

Tat (48-60)

HIV-1 protein

GRKKRRQRRRPPQQ

     plsl

Igl-1 homeodomain

RVIRVWFQNKRCKDKK

STR-R8

Stearly-RRRRRRRR-amide (Stearyl = CH3(CH2)16CO-)

STR-(RxR)4

Stearly-(RxR)4-amide (X=6-aminohexanoic acid)